General description
Anti-MAST3 Antibody detects endogenous levels of total MAST3 protein. Microtubule associated serine/threonine kinase 3 (MAST3) belongs to the MAST kinase family. It is composed of 1309 amino acids. The MAST3 gene is 53.9kb long and has 27 exons. It is localized on human chromosome 19p13.11. MAST3 possesses four α-helix bundles having various domains, including a protein kinase domain and a PDZ domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human MAST3.
Immunogen Range: 1031-1080
Biochem/physiol Actions
Microtubule associated serine/threonine kinase 3 (MAST3) modulates the activity of nuclear factor κ-B (NF-κB). It may have a role in inflammatory pathways. Knockdown of MAST3 has been shown to reduce NF-κB activity, which is dependent on toll-like receptor-4.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 143 kDa |
| species reactivity | mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:10000,western blot: 1:500-1:1000 |
| NCBI accession no. | O60307 |
| UniProt accession no. | O60307 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MAST3(23031) |
