产品介绍
Product Description
Biochem/physiol Actions
AZD0530 is an orally active, potent tyrosine kinase inhibitor against Src family kinases (IC50 = 2.7 nM/c-Src, <4 nM/Lck, 4 nM/c-Yes, 5 nM/Lyn, 10 nM/Fyn, 10 nM/Fgr, 11 nM/Blk), v-Abl (IC50 = 30 nM) and EGFR (L861Q/L858R/wt IC50 = 4/5/66 nM). AZD0530 exhibits anti-proliferation activity in cancer cultures (IC50 = 80-700 nM; Src Y530F NIH 3T3, LoVo, K562, PC-9, SW 403, PC-3) and shows efficacy against several human tumor xenograft growth in mice in vivo (6.25-50 mg/kg/day p.o.; MDA-MB-231, AsPc-1, Calu-6, BT474C).
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Clc1c(c6c(cc1)OCO6)Nc2ncnc3c2c(cc(c3)OCCN5CCN(CC5)C)OC4CCOCC4 |
| InChI | 1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31) |
| InChI key | OUKYUETWWIPKQR-UHFFFAOYSA-N |
