General description
Anti-C/EBP-β Antibody detects endogenous levels of total C/EBP-β protein.
CCAAT/enhancer-binding protein-β (C/EBP-β) is encoded by the gene mapped to human chromosome 20q13.13. The encoded protein belongs to the C/EBP family. C/EBP-β is a leucine-zipper transcription factor and is highly expressed during the early stages of adipocyte development. Alternative splicing of C/EBP-β leads to the formation of three isoforms such as, C/EBPβ-1 with 346 amino acids, C/EBPβ-2 with 323 amino acid and C/EBPβ with 146 amino acids.
Immunogen
The antiserum was produced against synthesized peptide derived from human C/EBP-beta.
Immunogen Range: 201-250
Biochem/physiol Actions
CCAAT/enhancer-binding proteins (C/EBPs) regulate expression of various cytokines and chemokines such as, interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1 (MCP-1). C/EBP-β plays a vital role in the regulation of gluconeogenesis and adipogenesis gene expression. The encoded protein also modulates the gene expression of human immunodeficiency virus-1 (HIV-1) and other retroviruses (human T-cell leukemia virus type (HTLV-) and simian immunodeficiency viruses (SIV)). This is carried out by regulating various process, like C-C chemokine receptor type 5 (CCR5) expression, virus promoter activities, cytokine and chemokine production and virus protein function. C/EBPβ is involved in various cellular processes such as metabolism, development and differentiation. Overexpression of C/EBP-β mRNA has been observed in various types of cancers.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 36 kDa |
| species reactivity | human, rat, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:10000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | P17676 |
| UniProt accession no. | P17676 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CEBPB(1051) |
