产品介绍
Product Description
Biochem/physiol Actions
Kinesore is a cell penetrant and potent activator of kinesin-1 that induces kinesin light chain tetratricopeptide repeat domain-dependent kinesin-1 activation in the absence of organelle cargo-adaptor engagement. It inhibits kinesin-1 interaction with peptide fragment of organelle-specific cargo adaptors. Kinesore induces kinesin light chain conformational switch that causes remodeling of the microtubule network in cells.
cell penetrant and potent activator of kinesin-1 that causes remodeling of the microtubule network in cells
技术参数
Specifications
| assay | >97% (HPLC) |
| form | powder |
| color | white to brown |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Brc1c(c(cc(c1)C(=O)N\N=C\c2c([n](c(c2)C)c3cc(ccc3)[N+](=O)[O-])C)Br)O |
| InChI | 1S/C20H16Br2N4O4/c1-11-6-14(12(2)25(11)15-4-3-5-16(9-15)26(29)30)10-23-24-20(28)13-7-17(21)19(27)18(22)8-13/h3-10,27H,1-2H3,(H,24,28)/b23-10+ |
| InChI key | DUGCMEGLYHBMAR-AUEPDCJTSA-N |
