Biochem/physiol Actions
PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events. It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.
Features and Benefits
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This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5 |
| InChI | 1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22) |
| InChI key | NVRXTLZYXZNATH-UHFFFAOYSA-N |
