General description
CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.
Biochem/physiol Actions
CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.
Physical form
Lyophilized from PBS
Preparation Note
Reconstitute with 100 μL deionized water.
Other Notes
Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| recombinant | expressed in CHO cells |
| tag | FLAG® tagged |
| assay | >95% (SDS-PAGE) |
| form | lyophilized |
| mol wt | 35-40 kDa by SDS-PAGE |
| packaging | pkg of 10 μg |
| storage condition | avoid repeated freeze/thaw cycles |
| impurities | <0.01 EU/μg endotoxin, tested |
| UniProt accession no. | P29965 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... CD40LG(959) |
