Application
Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-
Biochem/physiol Actions
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound.
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).
| Quality Level | 100 |
| assay | ≥95% (NMR) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 20 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | [P](=O)(O)(O)CCCN(O)C=O |
| InChI | 1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10) |
| InChI key | GJXWDTUCERCKIX-UHFFFAOYSA-N |
