General description
Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and / or cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
Immunogen
Synthetic peptide from C-terminus of human cyclin D1.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| recombinant | expressed in proprietary host |
| conjugate | unconjugated |
| antibody form | tissue culture supernatant |
| antibody product type | primary antibodies |
| clone | SP4, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | frog, dog, mouse, chicken, rat, bovine |
| technique(s) | immunoblotting: 1:25,immunohistochemistry: 1:100 |
| isotype | IgG |
| UniProt accession no. | P24385 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CCND1(595) |
