规格
|
|
Assay Entry:
|
Biochemical binding/kinetic |
|
Kinase Group:
|
Serine/Threonine Kinase |
|
Target Entry:
|
DYRK2 |
|
Species:
|
Human |
|
Validated Application:
|
Kinase Assay |
|
Molecular Weight:
|
92.9 kDa |
|
Gene Alias:
|
FLJ21217, FLJ21365 |
|
Protein Tag:
|
GST Tag |
储存
|
Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E. coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. DYRK2 also regulates p53 to induce apoptosis in response to DNA damage. Recombinant full-length human DYRK2 was expressed in E. coli cells using an N-terminal GST tag.
• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use
Related Product:
LanthaScreen® Eu Kinase Binding Assay
