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规格 |
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| Accession Number: | NM_000861.3 |
| Assay Entry: | Cell-based beta lactamase reporter gene |
| Cell Line: | 293T (HEK) |
| Cell State: | Dividing Cells |
| Druggable Target: | GPCRs |
| Gene Symbol: | H1 |
| Population Status: | Single Cell Clone Origin |
| Product Line: | GeneBLAzer® |
| Reporter Gene: | BLA (Beta-Lactamase) |
| System Type: | GeneBLAzer™ |
| Target Entry: | HRH1, H1 |
| Technique: | FRET |
| Detection Method: | Fluorescent |
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储存 |
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Contents: K1703 GeneBLAzer® H1-NFAT-bla HEK293T cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • GeneBLAzer® H1-NFAT-bla HEK293T cells • GeneBLAzer® H1-NFAT-bla HEK293T Assay Protocol • Certificate of Analysis Storage: The GeneBLAzer® H1-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt. |
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描述 |
GeneBLAzer® H1-NFAT-bla HEK293T cells contain the human Histamine Receptor 1 (H1) stably integrated into the CellSensor® NFAT-bla HEK293T cell line. CellSensor® NFAT-bla HEK293T cells (Cat. no. K1538) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® H1-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations Histamine. In addition, GeneBLAzer® H1-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The H1 receptor is located in human bronchi, bronchioles, and bronchial muscle, smooth muscle of the ileum, and the uterus. H1 receptors play a role in various disorders, including allergic reactions and mood disorders.
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