Clone REA314 recognizes the human Nanog antigen, a homeobox transcription factor also known as ES cell–associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC), and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Inhibition of Nanog expression has led to a reduction in tumorigenicity and such in vitro characteristics of stem cells as anchorage independent growth whereas overexpression may increase tumorigenicity.
Additional information: Clone REA314 displays negligible binding to Fc receptors.
Homeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog (hNanog)
Technical specifications
