产品介绍
Product Description
Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4+CD25+ Tregs.
Additional information: Clone REA980 displays negligible binding to Fc receptors.
GITR, TNFRSF18, AITR
Technical specifications
