产品介绍
Product Description
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规格 |
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| Accession Number: | NP_002750.1 |
| Assay Entry: | Biochemical terbium phospho-specific activity, Biochemical binding/kinetic |
| Kinase Group: | Ser⁄Thr Kinases: Other |
| Shipping Condition: | Dry Ice |
| System Compatibility: | LanthaScreen® Antibody, LanthaScreen® Substrate |
| Target Entry: | EIF2AK2 |
| Target Gene: | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Expression System: | Baculovirus |
| Protein Family: | Kinases & Inhibitors |
| Protein Form: | Recombinant, Catalytic |
| Protein Subtype: | Serine⁄Threonine Kinases |
| Research Category: | Signal Transduction |
| Species: | Human |
| Validated Application: | Kinase Assay |
| Gene ID (Entrez): | 9833 |
| Molecular Weight: | 62.2 kDa |
| Gene Alias: | EIF2AK2 (PKR) |
| KinaseFamily: | PEK Kinase Family |
| Protein Length: | aa 252-551 |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris, pH 7.5, 50% glycerol, 0.5 mM EDTA, 0.02% Triton X-100, 150 mM NaCl, 2 mM DTT Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection.
