规格
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Accession Number:
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NP_940980.3 |
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Protein Form:
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Full Length |
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Research Category:
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Neurobiology |
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Species:
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Human |
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Molecular Weight:
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288 kDa |
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Quantity:
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1mg |
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Gene Alias:
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AURA17, DARDARIN, PARK8, RIPK7, ROCO2 |
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Validated Application:
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Kinase Assay |
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Expression System:
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Mammalian |
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KinaseFamily:
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LRRK Kinase Family |
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Protein Tag:
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DYKDDDDK |
储存
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Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.
Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton®X–100, 2 mM DTT, and 50% glycerol. |
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® TR-FRET Kinase Activity Assay
