CD3 MicroBeads were developed for positive selection or depletion of CD3+ T cells from peripheral blood, bronchial lavage, cell culture, or various tissues such as lymphoid, nasal, and tumor tissue.
Detailed product information
Background information
CD3 is expressed on all T cells and CD56+ NKT cells, and is associated with the T cell receptor. 70–80% of human peripheral blood lymphocytes and 65–85% of thymocytes are CD3+. The epitope recognized by CD3 MicroBeads is located on the CD3ε chain.
Downstream applications
T cells isolated by MACS® Technology have been used for various studies, e.g., on T cell cytotoxicity, T cell activation1, HIV infectivity2, signal transduction, and surface marker expression.
Columns
For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.
