产品介绍
Product Description
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规格 |
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| Accession Number: | NP_000133; K650E |
| Assay Entry: | Biochemical terbium phospho-specific activity, Biochemical binding/kinetic |
| Kinase Group: | Tyrosine Kinases |
| Mass: | 10 µg |
| Protein Form: | Recombinant, Cytoplasmic |
| Research Category: | Oncology, Signal Transduction |
| Shipping Condition: | Dry Ice |
| Species: | Human |
| System Compatibility: | LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate |
| Tag Position: | N-Terminal |
| Target Entry: | FGFR3 K650E |
| Target Gene: | fibroblast growth factor receptor 3 |
| Molecular Weight: | 49.8 kDa |
| Protein Subtype: | Receptor Tyrosine Kinases |
| Gene Alias: | FGFR3 K650E |
| Validated Application: | Kinase Assay |
| Protein Family: | Kinases & Inhibitors |
| Expression System: | Baculovirus |
| KinaseFamily: | FGF Receptor Kinase Family |
| Protein Length: | aa 398-806; K650E |
| Protein Tag: | His Tag |
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储存 |
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Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.
