Clone REAL592 is an antibody fragment derived from the full Lamin A/C antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL592 recognizes Lamin A/C (Prelamin A/C), member of the lamin protein family, that are encoded by the LMNA gene. Lamin A and C are found in equal proportions in the lamina of mammals. Lamins are nuclear membrane structural components, that are thought to be involved in the regulation of the cell cycle, gene expression, nuclear stability, cell differentiation and apoptosis. Prelamin A/C can accelerate smooth muscle cell senescence by disrupting mitosis and induce DNA damage, leading to mitotic failure and genomic instability. Mutations in this gene lead to several diseases such as Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
LMNA, LMN1, LMNL1, MADA, Prelamin-A/C, PRO1, CMD1A,, LGMD1B, Renal carcinoma antigen, NY-REN-32
Technical specifications
