Clone REA257 recognizes the C-C motif chemokine 3 (CCL3) antigen also known as macrophage inflammatory protein 1 alpha (MIP-1α). CCL3 is a cytokine belonging to the members of the β (CC) subfamily of chemokines. It is produced by T cells, B cells, Langerhans cells, neutrophils, and macrophages. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation and plays a role as a chemoattractant of monocytes, B cells, eosinophils, and cytotoxic T cells. It has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. The functional receptor for CCL3 has been identified as CCR1 and CCR5.
Additional information: Clone REA257 displays negligible binding to Fc receptors.
G0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein
Technical specifications
