产品介绍
Product Description
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规格 |
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| Accession Number: | NP_003945.2 |
| Kinase Group: | Ser⁄Thr Kinases: STE Group |
| Shipping Condition: | Dry Ice |
| Expression System: | Baculovirus |
| Form: | Frozen |
| Protein Form: | Catalytic |
| Research Category: | Drug Development |
| Species: | Human |
| Validated Application: | Kinase Assay |
| Molecular Weight: | 96.9 kDa |
| Quantity: | 100μg |
| Gene Alias: | MAP3K14 (NIK) |
| KinaseFamily: | STE Unique Kinase Family |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.02% Trition X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes.
