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规格 |
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| Accession Number: | BC028135.1 |
| Assay Entry: | Cell-based beta lactamase reporter gene |
| Cell Line: | CHO-K1 |
| Cell State: | Dividing Cells |
| Druggable Target: | GPCRs |
| Gene Symbol: | P2RY2 |
| Population Status: | Single Cell Clone Origin |
| Product Line: | GeneBLAzer® |
| Reporter Gene: | BLA (Beta-Lactamase) |
| System Type: | GeneBLAzer™ |
| Target Entry: | P2RY2 |
| Technique: | FRET |
| Detection Method: | Fluorescent |
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储存 |
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Contents: K1722 GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells • GeneBLAzer® P2RY2-NFAT-bla CHO-K1 Assay Protocol • Certificate of Analysis Storage: The GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt. |
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描述 |
GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells contain the human Purinergic receptor P2, G protein-coupled, 2 (P2RY2) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of ATP. In addition, GeneBLAzer® P2RY2-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
P2RY2 expression has been identified in smooth muscle, skeletal muscle, heart, spleen, lymphocytes, macrophages, bone marrow, lung, intestine, placenta, brain, kidney, and liver. P2RY2 has been implicated in the induction of chloride secretion in airway epithelial tissue, increases in coronary blood flow by vasodilation, and epidermal homeostasis.
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