产品介绍
Product Description
General description
A cell-permeable, potent inhibitor of human MMP-3 (stromelysin; Ki = 130 nM).
A potent and cell-permeable inhibitor of human MMP-3 (Ki = 130 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
human MMP-3
Product does not compete with ATP.
Reversible: no
Target Ki: 130 nM against human MMP-3
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kato, N., et al. 2002. Genome Informatics13, 272.
MacPherson, L.J., et al. 1997. J. Med. Chem. 40, 2525.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (TLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | white |
| solubility | DMSO: 30 mg/mL,ethanol: 8 mg/mL |
| shipped in | ambient |
| storage temp. | 10-30°C |
| SMILES string | [S](=O)(=O)(N(CC(C)C)CC(=O)NO)c1ccc(cc1)OC |
| InChI | 1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16) |
| InChI key | JIRXORZYIXSWOB-UHFFFAOYSA-N |
