General description
Scavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.
~61 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
Epitope: Extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.
Application
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SCARB1 in human adrenal gland tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Detect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.
Physical form
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human adrenal tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 5B8.2, monoclonal |
| species reactivity | human |
| concentration | 1 mg/mL |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgMκ |
| NCBI accession no. | NP_005496 |
| UniProt accession no. | Q8WTV0 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SCARB1(949) |
