General description
Angiotensin-converting enzyme (ACE) is a zinc-metallopeptidase belonging to the peptidase M2 family. It catalyzes the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, which increases the vasoconstrictive effects of angiotensin. The Angiotensin-converting enzyme plays an important role in maintaining cardiac function and vascular tone. It is highly expressed in the heart, lung, kidney, gastrointestinal system, and prostate. Defects in the Angiotensin-converting may contribute cardiac disease; and renal tubular dysgenesis, a condition characterized by persistent fetal anuria and perinatal death.
~180 kDa observed. The calculated molecular weight is 150 kDa; however, this protein is known to be glycolsylated.
Immunogen
Human Angiotensin Converting Enzyme.
Application
Anti-Angiotensin Converting Enzyme Antibody, clone 2E2.
Physical form
Mouse monoclonal IgG1 cultured supernatant without preservatives.
Analysis Note
Control
Rat Angiotensin Converting Enzyme
Evaluated by Western Blot in rat Angiotensin Converting Enzyme.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected rat Angiotensin Converting Enzyme in WB.
Other Notes
Replaces: MAB3502
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| clone | 2E2, monoclonal |
| species reactivity | rat |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | western blot: suitable |
| isotype | IgG1 |
| NCBI accession no. | NP_000780 |
| UniProt accession no. | P12821 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... ACE(1636) |
