产品介绍
Product Description
General description
Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
技术参数
Specifications
| biological source | human |
| Quality Segment | 100 |
| form | liquid |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable |
| NCBI accession no. | NM_019887 |
