General description
The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.
~62 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human LGI3.
Application
Detect the LGI3 protein using this Anti-LGI3 validated for use in WB.
Biochem/physiol Actions
Two isoforms of LGI3 are known to exist; this LGI3 antibody will recognize both.
Analysis Note
Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected LGI3 in 15 µg of human brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q8N145 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... LGI3(203190) |
