General description
38 kDa
The SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3′ end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human SLBP.
Application
Immunocytochemistry:
Representative lot data.
Confocal fluorescent analysis of NIH/3T3 cells using 06-1376 (Red). Actin filaments have been labeled with AlexaFluor
Research Sub Category
RNA Metabolism & Binding Proteins
Histones
Use Anti-SLBP Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect SLBP also known as Histone stem-loop-binding protein, HBP, Histone RNA hairpin-binding protein.
Biochem/physiol Actions
Antibody recognizes SLBP.
Physical form
Serum in buffer containing 0.05% sodium azide
Analysis Note
Control
C2C12 cell lysates.
Evaluated by Western Blotting in C2C12 cell lysates.
Western Blotting Analysis: A 1:1000 dilution of this antibody detected SLBP in C2C12 cell lysates.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | serum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | rat |
| technique(s) | immunocytochemistry: suitable,western blot: suitable |
| NCBI accession no. | NM_009193 |
| UniProt accession no. | P97440 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SLBP(7884) |
