General description
Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
~71 kDa
Immunogen
Epitope: C-Terminus
Syntheic linear peptide.
Application
Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Biochem/physiol Actions
Cat. AB15242 recognizes the C-terminus of zDHHC8.
Physical form
ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Analysis Note
Control
Fetal human brain
Routinely evaluated by western blot in fetal human brain lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | rat, human |
| species reactivity (predicted by homology) | horse, bovine, Xenopus, chicken, pig, chimpanzee, ape, opossum, mouse, dog |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9ULC8 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | chimpanzee ... Zdhhc8(458662) human ... ZDHHC8(29801) |
