General description
A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Hence, serves as a selective peroxynitrite scavenger and decomposition catalyst. Provides cytoprotection against peroxynitrite (EC50 = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.
Biochem/physiol Actions
Cell permeable: no
EC50 = 5 µM for cytoprotection against peroxynitrite
Primary Target
Selective peroxynitrite scavenger
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Other Notes
Imam, S.Z., et al. 2000. Ann. N.Y. Acad. Sci.914, 157.
Misko, T.P., et al. 1998. J. Biol. Chem. 273, 15646.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (TLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | dark brown |
| solubility | water: soluble |
| shipped in | ambient |
| storage temp. | 2-8°C |
