General description
53 kDa calculated
Glucagon-Like Peptide 1 Receptor (GLP-1R) is the receptor for glucagon-like peptide 1 and is expressed in the pancreatic beta cells. Ligand binding activates adenyl-cyclase activity which results in increased insulin synthesis and release. GLP-1R is also expressed in the brain where it functions in the control of appetite, memory and learning. GLP-1R also has neuroprotective functions which may be beneficial in diseases such as Huntington′s disease, and drugs that are GLP-1R agonists (acts like natural ligand to activate the receptor) such as Exendin-4 are being examined as potential therapies for the disease as well as diabetes and other memory and metabolic disorders.
Immunogen
Epitope: extracellular domain, near N-Terminus
KLH-conjugated linear peptide corresponding to the extracellular domain of Human Glucagon-Like Peptide 1 Receptor.
Application
Research Category
Metabolism
Signaling
Research Sub Category
Lipid Metabolism & Weight Regulation
Lipid Signaling
This Anti-GLP1R Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of GLP1R.
Physical form
Antigen Affinity Purified
Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Immunohistochemistry (Paraffin) on endocrine cells in human pancreas.
Immunohistochemistry Analysis: 2 ug/ml this antibody showed cytoplasmic staining of subsets of endocrine cells in islets of Langerhans in human pancreas.
Other Notes
Concentration: Please refer to lot specific datasheet.
Replaces: AB9433
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | immunohistochemistry: suitable (paraffin) |
| NCBI accession no. | NP_002053 |
| UniProt accession no. | P43220 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... GLP1R(2740) |
