General description
Potent inflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema.
Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Polymorphonuclear leukocytes
Product does not compete with ATP.
Reversible: no
Physical form
In Ethanol.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kendall, A.P., et al. 1995. Anesthesia 50, 590.
Dokter, W.H., et al. 1994. Leukemia 8, 1181.
Jedlitschky, G., et al. 1991. J. Biol. Chem.266, 24763.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Flammable (J)
| description | Merck USA index - 14, 5455 |
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | oil |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | clear |
| solubility | ethanol: soluble |
| shipped in | wet ice |
| storage temp. | −70°C |
| SMILES string | OC(CCCC(=O)O)\C=C\C=C\C=C\C(O)C\C=C\CCCCC |
| InChI | 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6+,14-10+,15-11+ |
| InChI key | VNYSSYRCGWBHLG-XUOUMLBJSA-N |
