General description
Peripherin-2 (PRPH2) is also called Retinal degeneration slow protein (RDS) and Tetraspanin-22 (Tspan-22). Peripherin-2 is a critical factor in ocular disk morphogenesis and possibly functions as an adhesion molecule helping to stabilize and compact outer segment disks, to help maintain curvature of the rim. Peripherin-2 is expressed in the photoreceptors of the retina and in the rim of rod outer segment (ROS) disks. Peripherin-2 defects are found in different retinal diseases including cone-rod dystrophy, retinitis pigmentosa, and macular degeneration.
~35 kDa observed
Immunogen
Epitope: Cytoplasmic domain
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Peripherin-2.
Application
Anti-Peripherin-2 Antibody, clone 6B10.1 is a highly specific mouse monoclonal antibody, that targets Peripherin & has been tested in western blotting & IHC.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Peripherin-2 in 10 µg of human retina tissue lysate.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Peripherin-2 in human retina tissue.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse eye tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in 10 µg of mouse eye tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 6B10.1, monoclonal |
| species reactivity | mouse, rat, human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_000313 |
| UniProt accession no. | P23942 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PRPH2(5961) |
