产品介绍
Product Description
General description
使用基于非细胞的测定法在发现管道中更早地提高候选药物的可预测性可以提高ADME阶段的候选通量。非基于细胞的渗透性测定是开发候选药物口服吸收的预测模型。
MultiScreen Permeability、MultiScreen-IP和MultiScreen Acceptor板支持用于预测被动转运的人工膜策略。
膜具有均匀的孔结构和密度以实现可靠的转运:
- 单个孔最小化候选串扰
- 与自动液体处理系统的兼容性增加了通量
渗透性测定：
- MultiScreen渗透板具有聚碳酸酯膜，可支持用于渗透试验的己烷/十六烷人工层。1
PAMPA测定：
- MultiScreen-IP板具有疏水性PVDF膜，支持PAMPA ASAys的脂质双层。2,3
MultiScreen Acceptor板：
- MultiScreen Acceptor板可以与任一板一起使用，以捕获被动转运的化合物。该板由100% PTFE构成，根据所评估的小分子的电荷，可以改善LC/MS结果。
过滤器代码：IP
Application
研究类别
测定
蛋白质
Physical form
色码：透明
Other Notes
自动化兼容：否
Legal Information
Immobilon is a registered trademark of Merck KGaA, Darmstadt, Germany
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany
技术参数
Specifications
| Quality Level | 400 |
| material | flat bottom wells,Durapore PVDF membrane,clear acrylic plate |
| description | This clear 96 well filter plate has a Hydrophobic PVDF membrane used for PAMPA.,without underdrain |
| sterility | non-sterile |
| usage | Manual |
| feature | hydrophobic,lid |
| packaging | pkg of 10 plates |
| manufacturer/tradename | MultiScreen® |
| technique(s) | cell based assay: suitable,dot blot: suitable,parallel artificial membrane permeation assay (PAMPA): suitable |
| plate size | 96 wells |
| well maximum volume | 300 μL |
| working volume | 50-250 μL |
| matrix | Immobilon®-P |
| pore size | 0.45 μm pore size |
| binding type | high binding surface |
| compatibility | manifold only |
| shipped in | ambient |
| storage temp. | no temp limit |
