General description
Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Nitric oxide scavenging action
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
Other Notes
Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥97% (TLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | dark blue |
| solubility | HEPES Buffer: 0.4 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
