General description
61 kDa calculated
Nectin-3, also known as Poliovirus receptor-related protein 3 (PVRL3) and PRR3, is thought to work with cadherin to form cell-cell adherens junctions. It is a transmembrane protein that is commonly found in the testis and in placental tissue. Nectin-3 colocalizes with CD155, the cognate receptor for poliovirus, to cell-cell junctions. Nectin-3′s involvement in down-regulation PVR from the cell surface leads to a reduction in cell motility and proliferation.
Immunogen
Full length recombinant protein corresponding to human Nectin-3.
Application
Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 detects level of Nectin-3/PVRL3 (CD113) & has been published & validated for use in FC.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
U251 cells
Evaluated by Flow Cytometry in U251 cells.
Flow Cytometry Analysis: 0.1 µg of this antibody detected Nectin-3 in U251 cells.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | N3.12.4, monoclonal |
| species reactivity | human |
| technique(s) | flow cytometry: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_056295 |
| UniProt accession no. | Q9NQS3 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... NECTIN3(25945) |
