General description
A cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F2α receptors linked to phospholipase C in astrocytes.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 20-50 µM against protein kinase C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
Other Notes
Berry, G.T., et al. 1994. Pediat. Res.35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci.5, 699.
Kitanaka, J., et al. 1993. J. Neurochem.60, 704.
Wang, X., et al. 1993. Biochem. J.290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol.59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res.50, 569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
| Quality Segment | 100 |
| description | Merck USA index - 14, 7326 |
| assay | ≥97% (TLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | white |
| solubility | acetone: soluble,ethanol: soluble,methanol: soluble |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | Oc1c(c(cc(c1)O)O)C(=O)CCc2ccc(cc2)O |
| InChI | 1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2 |
| InChI key | VGEREEWJJVICBM-UHFFFAOYSA-N |
