Application
Detect Endothelin-1 using this Anti-Endothelin-1 Antibody, clone IC4 validated for use in IC.
Development of Immunoradiometric assay (IRMA) for endothelin ET-1 which as a circulating plasma peptide has been associated with a variety of disease studies such as diabetes, hypertension, cardiogenic shock, acute myocardial infarction and uraemia.
Suitable for immunohistochemistry on frozen sections
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism
Hormones & Receptors
Biochem/physiol Actions
Recognizes endothelin ET-1 (10% cross-reactivity with ET-3) and when used in conjunction with CBL87 (anti-endothelin C-terminus) has a sensitivity of 0.06 pmol/L for ET-1.
Physical form
Format: Purified
Liquid in 0.02 M PBS with 0.25 M NaCl, pH 7.6. Contains 0.1% sodium azide.
Protein A purified
Preparation Note
For use within 1 month of purchase when stored at +4°C, for long-term storage, aliquot antibody into small volumes and store at -20°C.
Analysis Note
Control
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| clone | IC4, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunohistochemistry: suitable |
| isotype | IgG1 |
| NCBI accession no. | NM_001955.3 |
| UniProt accession no. | P05305 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... EDN1(1906) |
