General description
55 kDa
ALK7 (ACVR1C activin A receptor, type IC; ACVRLK4) is a transmembrane type IC receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. The type I receptors (i.e. ALK7) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK7 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK7.
Immunogen
Synthetic peptide designed against the N-terminal region of human ALK7
Application
Anti-ALK7 Antibody is an antibody against ALK7 for use in WB.
Research Category
Signaling
Research Sub Category
Cytokines & Cytokine Receptors
Developmental Signaling
Growth Factors & Receptors
Biochem/physiol Actions
Recognizes ALK7
Physical form
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.
Affinity purified using immunogen
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Routinely evaluated by western blot on either human or rat brain lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | rat, mouse, human |
| manufacturer/tradename | Upstate® |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_660302 |
| UniProt accession no. | Q8NER5 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... ACVR1C(130399) mouse ... Acvr1C(269275) rat ... Acvr1C(245921) |
