General description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
Immunogen
A synthetic phosphorylated peptide around S727 of human STAT1 (NP_009330.1).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 83, 87 |
| species reactivity | mouse, human, rat |
| concentration | 1.31 mg/ml |
| technique(s) | immunohistochemistry: 1:50-1:100,immunoprecipitation (IP): 1:50-1:100,western blot: 1:500-1:2000 |
| UniProt accession no. | P42224 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer727) |
| Gene Information | human ... STAT1(6772) |
