General description
The antibody detects endogenous level of total Tubulin -βIII protein.
Tubulin β-III (TUBB3) is a constituent of microtubules. It is expressed in mature neurons. It is located on human chromosome 16q24.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Immunogen
Peptide sequence around aa. 442-446 (E-E-S-E-A), according to the protein NP_006077.2
Application
Anti-Tubulin β-III antibody has been used in immunocytochemistry and western blot analysis.
Biochem/physiol Actions
Upregulation of tubulin β-III (TUBB3) shows vigorous tumor characteristics and genetic instability in urinary bladder cancer. It participates in the separation of chromosome. Individuals with congenital fibrosis of the extraocular muscle type 3 (CFEOM3) show mutations in TUBB3. βIII-tubulin modulates glucose metabolism, thereby transforms glucose starvation stress signaling to develop the multiplication of cell and survival in non-small cell lung cancer cells.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~55 kDa |
| species reactivity | mouse, human |
| concentration | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (E-E-S-E-A) |
| NCBI accession no. | NM_006086.3 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TUBB3(10381) |
