Anti-Transferrin antibody produced in goat，2ML，T2027-2ML，Sigma

General description

Transferrin is a bilobed glycoprotein. The polypeptide chain of transferrin is composed of two homologous lobes i.e N- and C- lobes. Each lobe is made of two domains N₁, N₂ and C₁, C₂ which are linked by a hinge. It has two specific sites for binding of Fe³⁺.

Application

Anti-Transferrin antibody has been used:

• in quantitative precipitin assay
• in enzyme linked immunosorbent assay (ELISA)
• in western blotting
• in immunoblotting

Biochem/physiol Actions

Transferrin is the major iron transporter protein that binds Fe(+3). The transferring-iron import system consists of a TonB dependent transporter (TbpA), and a lipoprotein co-receptor (TbpB) and both proteins work together in the transport of iron across the membrane.
Transferrin plays a major role in providing iron as a source for haemoglobin synthesis. It binds to the transferrin receptor 1(TfR1).

Preparation Note

treated to remove lipoproteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.