General description
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18), a nuclear-encoded integral protein, is located in the mitochondria. It is also a phosphatidylinositol 3-kinase-dependent protein. MTP18 comprises three α-helical stretches or transmembrane (TM) domains of high hydrophobicity. The MTFP1 gene is located on human chromosome 22q12.2.
Immunogen
Fusion protein corresponding to a region derived from internal residues of human mitochondrial fission process 1
Application
Anti-MTFP1 antibody produced in rabbit has been used in western blot (1:1000).
Biochem/physiol Actions
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18) controls mitochondrial fission Hence it helps to maintain the morphology of the mitochondria. Overexpression of MTP18 can facilitate fragmentation of the mitochondria. Loss-of-function of MTFP1 protein promotes cell death. It is crucial for cell viability.
The antibody detects endogenous levels of total MTFP1 protein.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 18 kDa |
| species reactivity | human, mouse |
| concentration | 1.8 mg/mL |
| technique(s) | immunohistochemistry: 1:50- 1:200,western blot: 1:500-1:2000 (Cell Lysate) |
| isotype | IgG |
| accession no. | NP_001003704.1 |
| UniProt accession no. | Q9UDX5 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MTFP1(51537) |
