General description
Anti-C1QB Antibody detects endogenous levels of total C1QB protein.
The C1QB (complement C1q B chain) gene is mapped to human chromosome 1p36.12 and codes for the subcomponent of C1q protein, which is part of C1 complex of the classical pathway. The encoded protein is predominantly expressed in neurons and glia. It is localized to the growing synapses. The encoded protein is a hexameric molecule consisting of three distinct types of 18 polypeptide chains.
Immunogen
The antiserum was produced against synthesized peptide derived from human C1QB.
Immunogen Range: 161-210
Biochem/physiol Actions
The protein encoded by C1QB (complement C1q B chain) gene is involved in synapse formation and offers neuroprotection in the central nervous system. In response to a number of immune and nonimmune ligands, C1q protein activates proteases C1r and C1s in order to trigger classical complement pathway. C1q protein is regarded as a major component of the humoral innate immune defense. C1q carries out opsonophagocytosis, inflammation, and cytolysis to eliminate pathogenic microorganism and harmful apoptotic cells. Mutations in the gene causes systemic lupus erythematosus. Variation in the gene is also linked to rheumatoid schizophrenia, arthritis, amyloidotic polyneuropathy, metastasis of cancer.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 26 kDa |
| species reactivity | human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:40000,immunofluorescence: 1:100-1:500,western blot: 1:500-1:1000 |
| NCBI accession no. | P02746 |
| UniProt accession no. | P02746 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... C1QB(713) |
