General description
Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.
Biochem/physiol Actions
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.
Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Physical form
Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2
Other Notes
One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.
View this factors role in the Coagulation Cascade
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
| biological source | human |
| Quality Segment | 200 |
| form | solution |
| specific activity | ≥1500 units/mg protein |
| mol wt | 168 kDa |
| technique(s) | ligand binding assay: suitable |
| UniProt accession no. | P12259 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... F5(2153) |
