General description
MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region.
Immunogen
Synthetic peptide directed towards the N terminal region of human MAFB
Biochem/physiol Actions
MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO).
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPE
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 36 kDa |
| species reactivity | human, rat, guinea pig, horse, bovine, mouse, dog |
| concentration | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9Y5Q3 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MAFB(9935) |
