产品介绍
Product Description
Biochem/physiol Actions
An acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against human, but not mouse or rat, FFA2 (GPR43)
CATPB is an acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against human, but not mouse or rat, FFA2 (GPR43). CATPB inhibits both constitutive and propionate (C3) -stimulated hFFA2 GTPγS incorporation (IC50 ~35 and 320 nM, respectively; [C3] = EC80, ~125 nM), as well as C3-induced hFFA2 G159E activity (IC50 ~400 nM). CATPB is shown to inhibit C3-induced intracellular ERK phosphorylation in hFFA2-expressing cells (IC50 ~3 μM against 10 mM C3).
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 10 mg/mL, clear |
| web metadata keyword.default | (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid,1322598-09-3 CATPB,CATPB Sigma-Aldrich,CATPB antagonist activity against FFA2,CATPB chemical with inverse agonist properties,CATPB derivative,CATPB for biochemical assays,CATPB for pharmaceutical research,CATPB for research,CATPB procurement for laboratory use,GPR43 antagonist CATPB chemical,high purity CATPB Sigma-Aldrich,lab-grade CATPB |
| storage temp. | 2-8°C |
| SMILES string | O=C(N[C@@H](CC1=CC=C(C(F)(F)F)C=C1)CC(O)=O)CC2=CC=CC(Cl)=C2 |
| InChI key | QOSIJVVNNGXEKE-INIZCTEOSA-N |
