产品介绍
Product Description
Biochem/physiol Actions
Chromeceptin binds to multifunctional protein 2 (MFP-2); inhibits Insulin-like growth factor 2 (IGF2) signaling.
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.
Features and Benefits
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | solid |
| color | yellow to brown |
| solubility | H2O: <2 mg/mL,DMSO: >20 mg/mL |
| storage temp. | −20°C |
| SMILES string | CN(C)c1ccc2C(c3cccc(c3)C(F)(F)F)C(C#N)=C(N)Oc2c1 |
| InChI | 1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3 |
| InChI key | GVINXTXGDDSXFQ-UHFFFAOYSA-N |
