General description
The antibody neutralizes receptor-ligand interaction. The antibody shows no cross-reactivity with recombinant human PlGF and recombinant human VEGF.
Immunogen
purified recombinant mouse placenta growth factor 2 expressed in insect Sf 21 cells.
Biochem/physiol Actions
Placental growth factors (PlGF) are involved in the growth, migration and survival of endothelial cells. All the four isoforms identified are expressed in placenta and umbilical vein endothelial cells. PlGF bind to specific Flt-1 receptors that result in activation and recruitment of dendritic cells, smooth muscle cells and inflammatory cells. PlGF2 has the ability to bind heparin while PlGF1 is a soluble isoform.
Physical form
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 62526, monoclonal |
| form | lyophilized powder |
| species reactivity | mouse |
| technique(s) | indirect ELISA: 0.5-1.0 μg/mL,neutralization: suitable,western blot: 1-2 μg/mL |
| isotype | IgG2a |
| UniProt accession no. | P49764 |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Pgf(18654) |
