产品介绍
Product Description
Application
Naloxone hydrochloride dihydrate has been used in:
- isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
- as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
- as a reference neutral antagonist to define the maximum effect (Emax) of the system
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
光敏。
技术参数
Specifications
| Quality Segment | 200 |
| assay | ≥98% (TLC and titration) |
| form | powder |
| optical activity | [α]25/D −178.6°, c = 2.5 in H2O(lit.) |
| color | white to off-white |
| solubility | ethanol: 3.3 mg/mL,H2O: 50 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C |
| InChI | 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1 |
| InChI key | TXMZWEASFRBVKY-IOQDSZRYSA-N |
| Gene Information | human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280) |
