General description
The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein composed of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Immunogen
Purified human CRP
Biochem/physiol Actions
The mouse monoclonal antibody C2 recognizes human CRP, an 117 kDa plasma acute phase protein; it recognizes the antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Physical form
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | unconjugated |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | C2, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| concentration | 1 mg/ml |
| technique(s) | ELISA: suitable,immunohistochemistry: suitable |
| isotype | IgG1 |
| UniProt accession no. | P02741 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CRP(1401) |
