General description
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Immunogen
recombinant soluble human DLL4
Biochem/physiol Actions
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Physical form
Phosphate buffered saline (PBS), pH 7.4
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | unconjugated |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | MHD4-46, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| concentration | 1 mg/ml |
| technique(s) | FUNC: suitable,flow cytometry: suitable |
| isotype | IgG1κ |
| UniProt accession no. | Q9NR61 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... DLL4(54567) |
